DCMP: Database of Cancer Mutant Protein Domains

(sponsored by DST-SERB)



  

Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. In 2020 there are predicted to be 20 million new cases and 12 million deaths. Analyses of well-studied cancers, such as colorectal cancer and retinoblastoma, have suggested that only three or less mutations are sufficient for cancer initiation. Group efforts taken from The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC), and Catalogue of Somatic Mutations in Cancer (COSMIC) were made possible to have thousands of cancer genome sequences. In recent years, the genetic landscapes of mutations have been revealed in several cancer types. However, this gene-based approach usually does not consider the position of the mutation within the gene or that which provides the functional context of the position of the mutation. Computational structural studies have explored mutational effects on specific regions of a protein (e.g., the binding site). Recently, we identified significant mutated domains on three cancer diseases: ovarian, breast and prostate cancer. Somatic mutations were mapped to individual protein domains and the local false discovery rate was used to identify significantly mutated domains in each cancer type. This serves as a basis for identifying potentially mutated domains among different cancer types.

List of Cancers

Cancer Types Mutated domains Mapped Percentage(%) Cancer Types Mutated domains Mapped Percentage(%)
Adrenal 1322 55.39 Lung 5190 50.80
Biliary 3377 49.07 Oesophagus 4423 49.71
Bone 2594 49.67 Ovary 3402 52.34
Brain 3791 51.58 Pancreas 3771 53.40
Breast 4901 49.15 Prostate 4286 48.52
Cervix 3280 46.74 Skin 5217 49.25
Endometrium 4952 49.53 Stomach 4822 49.81
Eye 209 65.99 Testis 198 56.65
Kidney 4117 50.40 Thyroid 4195 47.35
Large Intestine 5327 49.84 Urinary 4714 48.54
Liver 5093 47.78